Polyunsaturated fatty acids and inflammation

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Polyunsaturated fatty acids and inflammation.

The n-6 polyunsaturated fatty acid, arachidonic acid, is a precursor of prostaglandins, leukotrienes and related compounds that have important roles as mediators and regulators of inflammation. Consuming increased amounts of long chain n-3 polyunsaturated fatty acids (found in oily fish and fish oils) results in a partial replacement of the arachidonic acid in cell membranes by eicosapentaenoic...

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Essential polyunsaturated fatty acids, inflammation and mortality in dialysis patients.

BACKGROUND Polyunsaturated fatty acids (PUFA) are essential nutrients with anti-inflammatory and cardioprotective properties. We investigated the association of essential dietary PUFA intake, reflected by plasma fatty acid composition, with inflammation and mortality in dialysis patients. METHODS We recruited 222 Swedish dialysis subjects (39% women) with median age of 57 years and average 12...

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N-3 Polyunsaturated Fatty Acids, Body Fat and Inflammation

BACKGROUND Based on animal studies, n-3 polyunsaturated fatty acids (PUFAs) have been suggested to lower the risk of obesity and inflammation. We aimed to investigate if, among humans, intake of n-3 PUFAs was associated with i) total body fat, ii) body fat distribution and iii) obesity-related inflammatory markers. METHODS The study population consisted of 1,212 healthy individuals with infor...

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n-3 Polyunsaturated fatty acids, inflammation and obesity-related disease.

Obese individuals are at increased risk from a range of metabolic diseases, including insulin resistance, dyslipidaemia and hypertension. Adipose tissue is an important endocrine organ, secreting a range of inflammatory mediators, including tumour necrosis factor alpha and interleukin 6. Circulating concentrations of these cytokines are increased in obesity and may contribute to the pathogenesi...

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n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases.

Inflammation is part of the normal host response to infection and injury. However, excessive or inappropriate inflammation contributes to a range of acute and chronic human diseases and is characterized by the production of inflammatory cytokines, arachidonic acid-derived eicosanoids (prostaglandins, thromboxanes, leukotrienes, and other oxidized derivatives), other inflammatory agents (e.g., r...

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ژورنال

عنوان ژورنال: Biochemical Society Transactions

سال: 2005

ISSN: 0300-5127,1470-8752

DOI: 10.1042/bst0330423